Biology/Immunity

A: The variant of concern VOC 202012/01 also known as the B.1.1.7 lineage accumulated many mutations in a short period of time and may spread more quickly than other strains. Researchers have located three specific mutations that may allow for increased transmission in this variant with continued study expected. It is likely the vaccine will Read more…

A: Yes, many variants of SARS-CoV-2 exist which is normal virus behavior. The changes noted to date warrant continued study, though should not cause alarm. Scientists study virus mutations to: 1) understand the family tree of virus strains 2) examine changes that could alter transmission and/or disease severity 3) examine changes that could alter the Read more…

A: It’s possible. #MaskUptoGetItUp TL;DR: Due to its impact on inflammation and the vascular system, it is biologically plausible that COVID-19 contributes to erectile dysfunction. But as with much COVID-19 research more, ahem, hard data is needed. This eyebrow raising headline made the rounds recently based on comments during a television interview by Dr. Dena Read more…

Drs. Lindsey Leininger and Malia Jones take your thorny COVID questions in this Live Q&A! If you have a question, submit it at our website! www.dearpandemic.org. This week we discuss: ➡️ Intro…with TV show rec’s! (0:00 – 3:00) Related link ➡️ The latest on quarantine timelines (3:35 – 8:40) Related link ➡️ Handling conspiracy theories Read more…

A: No. Evidence on the longevity and strength of the immune system response to SARS-CoV-2 remains inconclusive. Previous infection does not give you an “immunity passport”. All individuals should continue to follow SMART precautions, particularly during the holiday season. Here is what we know to date. Antibody testing alone is an insufficient measure of immunity. Read more…

A: Maybe; there *is* evidence of antibodies to seasonal coronaviruses reacting to some parts of the SARS-CoV-2 virus. BUT so far there is no solid evidence that these antibodies protect from COVID-19 infection or disease. What does it mean to have “cross-reactive” antibodies? There are four “common” or seasonal human coronaviruses which are one cause Read more…

A: No need to panic, but scientists are keeping an eye on it. RNA viruses like SARS-CoV-2 are always mutating in small ways– this is normal and expected. While scientists will be watching closely, so far there is no solid evidence that this new mutation has changed the virus in meaningful ways. In a press Read more…

Drs. Lindsey Leininger & Malia Jones tackle your COVID questions, including what’s up with curfews, immunity passes, and declining death rates. ➡️ Intro and website info (:00 – 3:59) ➡️ Lightning round (4:00 – 9:39) ➡️ Immunity: personal + herd (9:40 – 17:55) ➡️ Curfews to curb spread? (18:30 – 25:15) ➡️ Cases up, death Read more…

A: So far it seems that short-term re-infection with SARS-CoV-2 is possible, but (hopefully) rare. A key question from the beginning of the pandemic has been what is the duration of immunity for SARS-CoV-2. Viruses like measles can provide lifelong immunity, but immunity to seasonal coronaviruses has generally been short-lived (around 12 months). One challenge Read more…

Q: Do we need to wipe the groceries again? Thanks for this great question from Kat in LA and Katey in the UK. A: No need to return to grocery wiping, but wipe down your phone regularly and keep those hands clean. A new study released last week from the Commonwealth Scientific and Industrial Research Read more…

A: Today we focus on the importance of sleep health as an evidence-based strategy for improving your immune system during the COVID-19 pandemic. ** Long-term sleep deficiency is associated with a range of co-morbidities (type 2 diabetes, cardiovascular disease, dementia) that put you at higher susceptibility and more severe outcomes of COVID-19. You can reduce Read more…

R: El término “inmunidad colectiva” o “inmunidad de rebaño”, es también llamado a veces “inmunidad comunitaria”, y se refiere a una situación en la que muchas personas de una población no son susceptibles a un virus, ya sea porque ya lo han tenido y es poco probable que lo vuelvan a contraer, o porque han Read more…

A: In short, neutralizing monoclonal antibodies are specialized proteins that can stop a particular virus from entering a cell and using it to make lots of copies of itself. Drug companies are developing a few different monoclonal antibodies intended to both prevent and treat COVID-19. When a virus gets inside your body and is identified Read more…

Q: Since they were already hit hard once, shouldn’t they have some herd immunity? A: Spain has seen an alarming increase in confirmed cases since mid-July, even surpassing the U.S. in daily cases per capita. But so far, deaths have only ticked up slightly compared to the height of their epidemic in March and April Read more…

A: Women may mount a stronger T cell response to SARS-CoV-2 infection, according to a recent paper in Nature from the lab of immunologist Dr. Akiko Iwasaki. In the study, researchers collected blood, saliva and other samples from 17 men and 22 women aged 60+ admitted to the hospital after a positive COVID-19 test and Read more…

Dear Pandemic: Follower Questions–Sept 5, 2020 Dr. Malia Jones and Dr. Lindsey Leininger crack open the follower question box and tackle your questions on this Facebook Live!   Link to original FB post

Update: We know there is on-going chatter about herd immunity. We are re-posting the explainer below, as little has changed as far as the assumptions for what it would take to achieve “natural” herd immunity. TL;DR: it’s bleak. Even at a theoretically lower threshold (50% vs 70%), the expected number of deaths is devastating. So Read more…

A: Not very. In the words of immunologist Dr. Akiko Iwasaki, “This is no cause for alarm – this is a textbook example of how immunity should work.” What do we know? In a press release yesterday, researchers described the first confirmed case of re-infection in a 33-year old Hong Kong man returning from Spain. Read more…